Preclinical evaluation of herbal plant in potassium oxonate induced hyperuricemia in mice

Objective: The objective of the study to perform Preclinical Evaluation Of Herbal Plant In Potassium Oxonate Induced Hyperuricemia In Mice.
Method: The present study was undertaken to investigate anti-gouty arthritic activity of aqueous leaves extract of Adhatoda vasaka using Potassium Oxonate induced hyperuricemia in mice. Potassium oxonate (PO) induced hyperuricemia in mice were determined by in vivo experiments. PO causes hyperuricemia in 1h after ip administration thus mice were administered PO followed by AVLE and standard drug treatment of Allopurinnol study conducted for 7 days finally measuring the serum levels of uric acid, xanthine oxidase, xanthine dehyrogenase, etc.
Results: The evaluation of anti-gouty arthritic potential by oral administration of AVLE (100-400 mg/kg) evoked a significantly decreased the serum levels of uric acid, xanthine oxidase (XOD), xanthine dehydrogenase (XDH) in treated mice.
Conclusions: The results obtained in this study indicate that AVLE possesses potential anti-gouty arthritic activity. Finally, the study concluded that in AVLE the flavonoidal constituitents impart enzyme inhibitory activity thus reducing levels of xanthine oxidase, xanthine dehyrogenase and serum uric acid.