Gliricidia sepium used for live fencing, fodder, firewood, green manure and intercropping. Gliricidia extract contains variety of bioactive compounds. Present study was aimed at a detailed investigation on secondary metabolites present in the leaf of Gliricidia sepium. The samples were extracted in ethanol, acetone and distilled water using Soxhlet apparatus, collected and stored at 40C. The extracts were evaporated and dried at 600C. The phytochemicals were screened following standard phytochemical investigation. Extract contained alkaloids, flavonoids, cardiac glycosides, steroids, tannins, carbohydrate and proteins. The findings of the study concluded that gliricidia leaf extracts have bioactive compounds that are used to overcome the problem of disease resistance.