Plants were being used in the treatment of diseases for centuries. In this present work, Coccinia.grandis, a traditionally significant plant has been studied for its potential medicinal properties. The fruits of this plant were used as the ingredient in variety of recipes all over the world. The leaves and fruits of C.grandis were collected and their ethanolic extracts were subjected to phytochemical screening and comparative analysis was done. HPLC was done to quantify the compounds present in the extracts. Antioxidant activity of the extracts was also carried out to determine the free radical scavenging efficiency of the extract. The results of the phytochemical analysis of the medicinal plant showed that the terpenoids, reducing sugar, flavonoids and proteins were found to be present in significant quantity. The comparative analysis Between the fruit and leaf extracts indicates that the fruit extract shows better antioxidant and phytochemical characteristics than the leaf extract.