Pemphigus vulgaris (PV) is a potentially life threatening disease that causes erosions and blisters of the skin and mucous membranes. It is a rare disease involve the mucosa and skin through the disintegration of cellular adherence (acantholysis), resulting in intradermal bullous disease. The lesions are usually painful and untreated generalized Pem¬phigus vulgaris may be a fatal one. A 39 year old male patient with known history of Pemphigus vulgaris completed DCP therapy I phase and is on interviewing oral Cyclophosphamide 50mg/day was admitted with chief complaints of new lesions since 2 days over scalp and trunk. Successful implementation of Dexamethasone-Cyclophosphamide-Pulse (DCP) therapy has reduced the mor¬tality rate dramatically along with other adjuvant drugs. Untreated, Pemphigus vulgaris is often fatal because of the susceptibility to infection and fluid-electrolyte disturbances hence, utmost importance to be given for PV treatment.