Paroxysmal nocturnal hemoglobinuria (PNH), which is characterized by intravascular hemolysis, bone marrow failure and venous thrombosis, is an acquired clonal disorder associated with a somatic mutation in a totipotent hematopoietic stem cell. It is a rare type of acquired hemolytic anemia that is frequently associated with pancytopenia. One such presentation was seen in a middle aged male who had history of severe anemia and jaundice. He was diagnosed to have pancytopenia, intravascular hemolysis, low vitamin B12 and folic acid level with responding hyperplastic marrow and on further workup was found to be a case of PNH.
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2022: 6.012
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