In the design of delivery method, convenience in administration as well as improved patient compliance find predominance. Oral dispersible tablets (ODTs) are solid dosage forms which disintegrate in the oral cavity in below 60seconds and have been taken without water. Swift disintegration followed by fast dissolution and rapid commencement of action are advantages of ODTs. Other advantages include improved stability and bioavailability. ODTs are suitable dosage forms in pediatrics, geriatrics, the mentally sick, nausea patients, and patients having trouble in consuming tablets and capsules. When ODTs in the tongue, they disintegrate immediately, delivering the drug, that breaks down in the saliva. Few medications are absorbed from the mouth, oesophagus, and pharynx, as the saliva passes through the stomach. In such instances, the bioavailability of a drug is remarkably greater than those noticed from conventional tablet dosage forms. Various methods in ODT manufacturing include – direct compression, spray drying, sublimation, melt extrusion, cotton candy process, etc.
Impact Factor
2022: 6.012
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