Osteocalcin-a hover or hyperlink in periodontitis

Osteocalcin levels have been postulated as a marker of inhibition of bone formation.Serum osteocalcin is presently considered a valid marker of bone turnover when resorption and formation are coupled, and a specific marker of bone formation, when formation and resorption are uncoupled. It may be involved in recruiting osteoclasts to sites of newly formed bone and thus may function as a negative regulator. In periodontitis, osteocalcin has been suggested to be a marker of bone formation where bone resorption is greater than formation, and GCF osteocalcin levels are more revealing than serum or saliva levels regarding bone turnover in periodontium.This paper highlights the role of osteocalcin as a potential marker of bone turnover in periodontal disease.