Infertility is defined as the failure to conceive pregnancy after 12 months of marital life. The chance to conceive depends on the length of sexual exposure, frequency of coitus, and couple’s age. The normal, young aged couples have a 25 % chance to conceive after 1 month of marital life; 70 % of the couple’s conceive within 6 months, and 90% of the couples have a probability to conceive by 1 year. Only 5% of the couples will conceive after one and a half year or two years. Both males and females are equally responsible for the infertility. Most of the infertile couples have one of these three major reasons including a azoospermia, oligospermia, asthenospermia. Ovulatory dysfunction, or tubal-peritoneal disease. Study population of 520 (both male and female) infertility patients was selected at surya fertility centre. Studies on psychological distress in men and women two parameters, stress and depression are compared in our study. We conclude that female infertility patients were in many aspects undergoing stress and depression compared to male along with the infertility treatment. To avoid serious complications in infertility patients treatment for psychiatric distress and depression such as patient counseling and some stress relief tools and counseling to the care takers should be given in order to manage stress levels and depression.