An observational study between diclofenac sodium, hyoscine n-butyl bromide and a combination of hyoscine n-butyl bromide with diclofenac sodium in providing pain relief in various age groups in cases of acute ureteric colic

Author: 
Rajat Girishkumar Gusani., Shirish Srivastava and Barna Ganguly

Introduction: Pain associated with Ureteric colic is severe and excruciating in nature. Anti-spasmodic have logically been given, but the pain relief has not been satisfactory. This study makes an attempt to compare the effects of Diclofenac Sodium alone and in combination & Hyoscine N-Butyl Bromide, in pain relief from Ureteric colic.
Materials and Methods: A prospective, randomized controlled study was conducted with a total of 120 patients, aged between 18 and 50 years, suffering from acute ureteric colic were included in this trial and randomly assigned in three groups. Patients in the first group (A) received Diclofenac, 75mg intravenous. The second group (B) received Hyoscine N-Butyl Bromide, 10mg intravenous & the third Group (C) received Diclofenac (75mg) & Hyoscine (10mg), intravenous. The pain intensity and vital signs were measured at the time of presentation and was reassessed at 0, 15, 30 and 45 minutes on a VAS scoring scale.
Results: After analysis, it was found that the pain relief at 45 minutes with Diclofenac sodium alone or in combination with Hyoscine was better than with Hyoscine N-Butyl Bromide (p = 0.001). It was also noted that the onset of relief of the pain was much quicker with Diclofenac sodium alone or in combination with Hyoscine than with Hyoscine N-Butyl Bromide (p = 0.013).
Conclusion: Diclofenac, when given as monotherapy or in a combination, has a significantly greater and quicker pain relief as compared to Hyoscine when given alone.

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DOI: 
http://dx.doi.org/10.24327/ijcar.2018.9810.1636
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