Aim and Objective: The objective of this study is to compare the effficacy of systemic enzyme therapy -Trypsin, Bromelain, Rutoside and zinc combination with diclofenac alone in the management of pain in osteoarthritis knee.
Materials and Methods: Randomized observational comparative study to compare the efficacy and tolerability of systemic enzyme therapy versus diclofenac in patients attending Orthopedic OPD with episodes of OA knee joint.
A total of 50 patients with osteoarthritis knee were included in the study, who were divided into two groups of 25 each. one group received diclofenac alone and the other group received a combination of of Trypsin, Bromelain and Rutoside with zinc. Both the groups were followed up for 6 weeks. The efficacy was determined by WOMAC scores, collected before and after the study period.
Results: The results of the study are as follows. Within our 6 weeks of observation period, WOMAC scores clearly indicate that the systemic enzyme therapy is equally effective as Diclofenac sodium in alleviating pain and reduction of edema. During the study period, both the drugs were well tolerated by both the study groups.
Conclusion: Osteoarthritis is a common painful joint disease, which is effectively treated with NSAIDs, most commonly Diclofenac; but carries the risk of gastric discomfort, gastric and duodenal ulcer and upper GI bleeding. Systemic enzyme therapy is superior in this aspect as they are free from these adverse effects.
Impact Factor
2022: 6.012
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