Background: The idea of treating different deformities or diseases with extracorporeal Shockwave Therapy in the maxillofacial region has been one of the emerging therapies. Shockwave therapy has been widely used for the management of urolithiasis and in traumatology.
Objectives: To evaluate the effect of the application of extracorporeal Shockwave Therapy on gingival fibroblast (PCS-201-018) and osteoblast-like cell lines (MG-63).
Methods: 20 gingival fibroblast and 20 osteoblast-like cell lines were included. They were divided as 10 cell lines each and considered as Control (no shockwave) and the remaining 10 cell lines were considered as Test group (shockwave) for both group of cell lines. Further analysed for cell-cell interaction using Scratch analysis through live imaging. Cell viability was analysed with MTT assay and ATP assay using bio-spectrometry.
Results: Encouraging results were observed for cell migration and proliferation in test cell lines. Cell viability was notably higher than the control cell lines. The calorimetric readings for intracellular ATP analysis were significantly higher for test compared to control cell lines.
Conclusion: The present in-vitro study showed promising effect of Shockwave Therapy on gingival fibroblast and osteoblast-like cell lines. This molecular study may pave way for application of shockwave therapy in situ for periodontal disease.
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