The periodontal disease is primarily a bacterial infection which lead to inflammatory changes along with host response, the chemical agents released by bacteria as well as the host response results in periodontal destruction. The host immune reaction when gets activated by matrix metalloproteins (MMPs), cytokines and prostanoids, can be reduced by therapeutic applications of anti-collagenase drugs (such as synthetic matrix metalloproteinase inhibitors), sub antibacterial-dose doxycycline (SSD) and chemically modified tetracycline’s (CMTs), anti-cytokine therapy using antiIL-1 or anti-tumor necrosis factor-α monoclonal antibodies and soluble tumor necrosis factor receptors and bisphosphonates. NSAIDs are the drugs that inhibit the formation of prostaglandins by blocking the cyclo-oxygenase pathway of arachidonic acid (proinflammatory mediators) metabolism.
Impact Factor
2022: 6.012
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