Neurofibroma is a benign neoplasm of non-odontogenic origin arising from peripheral nerves.They may present as a solitary lesions or in association with syndromic conditions. The solitary neurofibromas of the oral cavity are rare ranging from 2%-7%. Neurofibroma along with numerous feeding capillaries is an unusual presentation in the oral cavity which mimicks the Neurovascular hamartoma. We hereby present a case of solitary nodular palatal swelling of neurofibroma mimicking neurovascular hamartoma in a 13 year old girl. Histological investigation showed proliferation of spindle shaped cells with wavy nuclei along with numerous large and small proliferating capillaries. Toluidine blue staining was done to demonstrate Mast cells. Immunohistochemistry showed positivity for S- 100 and negativity for CD-34 based on which a final diagnosis of Neurofibroma was made.
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