Most reliable animals models of parkinson’s disease for screening new chemical entities

Parkinson’s disease is an auto degenerative disorder of the motor system in the central nervous system. It is caused due to the death of the dopamine generating cells of the mid brain. Parkinson’s disease is considered a synucleiopathy due to an abnormal accumulation of alpha -syncline protein in the brain in the form of Lewy bodies, as opposed to other diseases such as Alzheimer's disease where the brain accumulates tau protein in the form of neuro fibrillary tangles. Many authors have given details regarding the chemicals that causes parkinson’s disease in various animal models which serve as the test subjects. This present review mainly focuses on briefly describing the present advanced chemicals which are used to induce Parkinson’s disease to animals.