Allium sativum (Garlic) is an extremely versatile and delicious vegetable mostly grouped under spices that possesses high nutritional as well as medicinal value underpinnings of their active constituents such as S‑allylcysteine, diallyl disulfide and diallyl trisulfide etc. Its ancient history of medication is near about 3000 year’s old and its cultivation documented in several regions of Asia, North Africa and Southern Europe. Nowadays, garlic is more preferable vegetable or spice over other because of its potential medicinal value and multifaceted pharmacological activities. The pharmacological activities includes anti-microbial (anti-fungal, anti-viral, anti-bacterial) anti-cancer, anti-oxidant, anti-diabetic, anti-inflammatory, anti-hypertensive, cardio-protective, neuroprotective and immunomodulatory etc. Moreover, these pharmacological activities are due to the presence of their active constituents, which are having richest amount of phenolic content. Available published data have unconcealed that healthy garlic diet capable to cut down the metastasis statein subjects and also facilitated the aggregated cell dissolution in tissue having malignancy. In this review, the overall objective is to explain briefly about its dosage, nutritional values, related chemistry profile, bio-availability, available phytoconstituents and more specifically its pharmacological or biological activities and its health benefits. Garlic clasp first rank (super spice) in nutrition and healthy vegetables due to presence of the richest amount of phenolic contents as compared to other vegetables or spices.
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