Melanoma is the most serious and one of the most malignant tumors of the skin. It accounts for about 5% of all primary skin malignancies but is also responsible for about 80% of all skin tumor deaths. According to the latest data from the Cancer Registry of Republic of North Macedonia, the number of patients with melanoma is constantly growing and is one of the tumors with the greatest expansion in recent times. Annual increase in the number of patients is 5-6%. In the Republic of North Macedonia in the period from 2008 to 2012 there was an increase in the mortality (55 death casesin 2008 and 64 in 2012). In 2012, 64 people died of melanoma at a rate of 3.1 per 100,000 inhabitants, of which 39 were men and 25 were women. The death rate for men is 3.8 per 100,000 men and the death rate for women is 2.4 per 100,000 women. In 2011 thetotal number of death cases is 56 and the mortality rate per 100,000is 2.7, while in 2009 and 2012 there was a significant increase in the number of death cases. In 2009 there were 69 death cases, with a rate of 3.4 and in 2012 - 64 death cases and a rate of 3.1 per 100,000 inhabitants. The more the population is educated, the greater are the chances of noticing and recognizing suspicious changes in the body and their timely response will accelerate to dermatological examination.