Introduction: Mast cells are multifunctional and intricate cells, playing a significant role in innate and acquired immunity. Apart from their role in maintaining homeostasis and inflammation, they are also associated with tumor angiogenesis. Angiogenesis is a multifarious process regulated by growth factors where mast cells act by releasing angiogenic factors and promoting tumor growth and metastasis. Aim: To histologically evaluate the number of mast cells in oral squamous cell carcinoma (OSCC). Material and method: 30 cases stained with 1% toluidine blue (each of 15 OSCC and 15 normal mucosa) were included in study and were evaluated using light microscope. Result: Increase in the mast cell count was observed in OSCC. Conclusion: A significant increase in mast cell count in OSCC was noted compared to normal mucosa signifying their contribution in tumor growth and progression.
Impact Factor
2022: 6.012
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