To study the impact of various diluents on evaluation parameters of orodispersible tablets of lamotrigine. Oro-dispersible tablets of lamotrigine were prepared by direct compression method using PVP K30 as binder, Lactose, Avicel 101, Avicel 102as diluents and superdisintegrantscroscarmellose sodium. A Taguchi L9 orthogonal array (33) design of experiment was applied to study the effect of independent variables i.e., different diluents (like Avicel 101, Avicel 102 and Lactose), total weight of the tablet (50mg, 75mg and 100mg) and percentage of superdisintegrant (1% ,2% and 3%) on disintegration time (DT) and percentage drug release as dependent parameter. One-way ANOVA was used in the analysis of Taguchi design of experiment to determine whether the factors are significantly related to the response. ODT formulations with Avicel 101, Avicel 102 & Lactose as diluents containing croscarmellose sodium were optimized. The formulations had weight variation (0.7-1.8%), hardness(2.3±0.5-2.6±0.56kg/cm2), friability (0.5±0.5-0.98±0.56 %), disintegration time (4.5±0.55-9.2±0.81sec), wetting time (4±0.32-13±0.77sec), water absorption ratio (70±0.32-192±1.16%) were found to have within USP limits. The formulations F2,F3,F5,F6,F8 and F9were optimized having less DT ranging from 4 sec to 10 seconds. There was no significant change in dissolution profile of the formulations. Tablets were stable for one-month. It can be concluded that total weight of the tablet, and type of diluents had influence on the dependent variables, but total weight of the tablet showed maximum impact on DT followed by use of different diluents.
Impact Factor
2022: 6.012
This work is licensed under a