Iron overload turmoil'' and "management of hemochromatosis

It is known that Toxic iron overload can be fatal. Iron poisoning is one of the most common toxic ingestion and one of the most deadly among children. “Excess of iron is harmful to the body as it may lead to deposition of iron in organs and cause organ failure. Hemochromatosis Is an iron-overload disease in which iron is directly deposited in the tissues (Liver,spleen,heart,pancreas and skin) .An abnormal gene on chromosome 6 is linked with hemochromatosis. The amino acid tyrosine in the normal protein encoded by this gene is replaced by cysteine. This abnormal protein is responsible for excessive iron absorption from the intestine which accumulates in various tissues leading to their damage and malnutrition. A gene called HFE is most often the cause of hereditary hemochromatosis. Primary hemochromatosis is unusual in India.