Background: The inability to provide effective postoperative analgesia is one of the major disadvantages of intravenous regional anesthesia (IVRA). We designed a prospective, cohort study to compare and evaluate the effect of adding paracetamol or ketorolac as adjuvants to 0.5% preservative free lignocaine for intravenous regional anesthesia on various parameters in IVRA.
Methods: The study was a prospective cohort study done in Government Medical College, Thrissur, from March 2014 to July 2015. The study subjects were American Society of Anaesthesiologists I and II patients of either sex, aged 20-60 years, weighing between 45kg – 65kg, undergoing elective forearm procedures in Govt. Medical College, Thrissur. Patients with major systemic illnesses like liver disease, kidney disease, raynauds disease and sickle cell anemia were excluded.
Results: The mean sensory block onset time was lower in lignocaine / paracetamol group (3.6 ± 1.9) compared to lignocaine/ ketorolac group (6.1± 2.1) which was statistically significant. Cases who were in lignocaine /paracetamol group reported pain early in first twenty and forty minutes, although statistically not significant (P value > 0.05). But patients in lignocaine /ketorolac group reported pain later at fifty to sixty minutes, although statistically not significant (P value > 0.05). Most cases who were in lignocaine /paracetamol group reported pain early in the post operative period, although statistically not significant (P value > 0.05).
Conclusion: The mean sensory block onset time was lower in patients who received IVRA with lignocaine paracetamol group. There was no statistically significant difference in the duration of analgesia as well as the post perative pain onset time in either lignocaine/ paracetamol or lignocaine/ ketorolac group.
Impact Factor
2022: 6.012
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