Introduction: Oral submucous fibrosis (OSMF) is a chronic precancerous condition associated with inflammatory and fibrotic changes in the deeper layers of connective tissue. Even though the etiology of OSMF is multifactorial; it is particularly associated with chronic and frequent chewing of areca nut. Micro trauma due to repeated chewing habit along with the carcinogenic effects of arecanut products in OSMF; induce inflammatory changes. C-reactive protein (CRP) is an acute phase protein; indicator of inflammatory response for any stimulus. Thus acute phase proteins may have significant prognostic value in early cancer diagnostics.
Materials and Methods: The study consists of 30 clinically and histologically diagnosed cases of OSMF taken as study group with an age range between 20 to 45 years and 30 control cases of same age range without any detectable oral lesions. All the cases were taken from the outpatient in the Department of Oral Medicine and Radiology, A.J. Institute of Dental Sciences, Mangalore.
The blood which was withdrawn from the subjects, was allowed to clot, later centrifuged, serum separated and bio chemically evaluated for c-reactive protein (CRP) LEVEL, serum separated and biochemically evaluated for C - reactive protein (CRP) level. Mean serum level of CRP in both the group was statistically evaluated using student’s t test and compared in SPSS software.
Results: The study revealed increased serum CRP level in OSMF patients compared to control group.
Conclusion: In the present study CRP was used as one of the prognostic marker to show the influence of inflammation on OSMF to evaluate the mechanisms by which inflammation influences the risk of cancer.
Impact Factor
2022: 6.012
This work is licensed under a