Human commensal Staphylococcus aureus has become one of the important reason of skin and soft tissue infections (SSTIs) today. Among them methicillin resistant Staphylococcus aureus (MRSA) play significant role in these SSTIs and some of them are becoming multidrug resistant. Although multidrug resistant strains of these MRSA isolates are more prevalent in healthcare associated skin and soft tissue infections (SSTIs) but now a days they are increasingly reported in those SSTIs that are associated with community settings. Here we presented a case series about increasing incidence of multidrug resistance among CA-MRSA causing skin and soft tissue infections (SSTIs).