Background: myeloperoxidase (MPO) a leukocyte enzyme acts as a first-line defender against microorganisms. However, increased MPO levels have been found to be associated with different diseases. Therefore, this study aimed to investigate whether MPO, a biomarker of inflammation and oxidative stress, increased in patients with diabetic foot ulcers (DFU)
Methods: Plasma MPO antioxidant enzyme activity superoxide dismutase (SOD), and the inflammatory, marker iterlukin-6(IL-6) were determined in 30 patients with DFU and 30 healthy subjects as control group using ELISA. All results were statistically analyzed.
Results A highly significant increase was found in the plasma level MPOin patients with DFU compared to control (P < 0.05). Plasma levels of antioxidants (SOD) were significantly decreased in the patient group (P < 0.05) compared to control. However, cytokines (IL-6) levels demonstrated a significant increase in DFU patients (P < 0.01).
Conclusion The results of the present study provide evidence that MPO, oxidative stress, inflammation are associated with risk of DFU that may have future facilitate the development better management of DFU.
Impact Factor
2022: 6.012
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