Background: Coronary angiography and percutaneous intervention (PCI) is an indispensable diagnostic and therapeutic procedure in cases of acute myocardial infarction (Acute MI). However it possesses a potential complication of renal failure due to contrast induced nephropathy (CIN). Occurrence of CIN prolongs the hospital stay and may even lead to death. A prospective study was conducted in a defence service hospital to assess the incidence of CIN in patients undergoing coronary angioplasty. Methods: Consecutive 407 patients who had undergone elective coronary angiography and percutaneous coronary intervention between 01 Dec 2011 to 31 Jan 2013 at tertiary level defence service hospital in Mumbai, India were included in the study. Written informed consent was taken from all the included patients. Patients less than 18 years of age were not included in the study. Pregnant and patients with preexisting renal disease were also excluded. Baseline renal function tests were conducted, followed by repetition of tests at 24 hours and 72 hours. Results: Contrast induced nephropathy was detected in 4.18 % of the patients. Patients with preexisting co morbidities specially diabetes, hypertension and old age showed higher risk of contrast induced nephropathy. Conclusion: The preexisting diseases predispose the patient to higher risk of contrast induced nephropathy. Modifiable risk factors should be addressed adequately to reduce incidence of renal impairment due to interventional procedures.