The mouth is colonized by variety of microorganisms from birth and most of them are commensals, they become pathogenic, when the host responses are altered. The factors which are responsible for maintaining oral health are the integrity of the mucosa, saliva, gingival crevicular fluid and their humoral and cellular immune component. Tissues of the immune system fall into two groups based upon their role inhost defense. Primary (or central) tissues such as immature immune cells, creating andeducating them during their differentiation into mature cells. The bone marrow andthymus are parts of the primary immune system. Secondary (peripheral) immuneorgans look after mature cells that are an active part of defense. It encompasses the rest of theimmune tissues: the spleen, the lymphatic system, lymphnodes and MALT. Of course it is not this simple and the spleen and MALT also help inthe maturation of immune cells.
Impact Factor
2022: 6.012
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