Growth pattern in juvenile idiopathic arthritis in relation to insulin growth factor-1 and s100a8/9 protein

Background: juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease which affect growth before age of 16 years. The growth hormone (GH)/insulin-like factor-1 (IGF-1) axis is a main regulator of linear growth, and the major part of circulating IGF-1 levels is liver derived. S100 calcium-binding proteins are associated with acute / chronic in¬flammatory disorders. The most familiar of S100 proteins is S100A8/A9 (cal¬protectin). The aim of our study was toevaluate the physical growth pattern in children with JIA. To measure the level of serum IGF-1 and to compare it with healthy controls subjects and also toassess serum S100 A 8/9 protein and its relation to growth pattern and IGF-1. Methods: The study was a case control study which included 40 patients of both sexes with (JIA), their ages will range from 6-10 years. All patients and controls were subjected to the following:- Growth Assessment and measure serum (IGF-1) level and S100 A8/9 protein. Results: There was statistically significant difference between Cases and Controls regarding height-for-age z-score (HAZ), 37.5% of cases were short stature were 10% in controls. There was statistically significant decrease in Weight and BMI among Cases versus Controls. Percentage of underweight of cases were higher among cases versus controls. There was statistically significant decrease in serum Insulin-like growth factor 1 among Cases versus Controls. There was statistically significant increase in S100A8/9 Protein among Cases than Controls. There were statistically significant positive correlation between IGF-1 and height.Conclusion: Short stature is common among JIA patients. Underweight of cases were higher among cases versus controls. Growth data were shifts. The levels of CRP were significantly higher in patients compared to controls. We reported that IGF-1 levels were significantly decreased in JIA compared to controls. Patients with JIA had significantly higher levels of S100A8/9 compared to controls. There were statistically significant positive correlation between IGF-1 and height.