Objective: The Glidescope video laryngoscope (GSVL) is a novel intubating device used for difficult airway management. In this randomised control trial, we have compared glidescope with flexible fibreoptic bronchoscope not only in terms of hemodynamic responses but also through various intubating parameters in anticipated difficult airway. Methods: Sixty-eight patients were randomly allocated to either glidescope (Group A) or fibreoptic group (Group B). Non-invasive blood pressure (NIBP), heart rate (HR)mean arterial pressure (MAP) and oxygen saturation (SpO2) were recorded before induction, after induction, before intubation, one, three, five and ten minutes after intubation. Number of attempts required for intubation, intubation time, additional manoeuvre to facilitate intubation, change of performer, mucosal/dental injury, post operative sore throat, Modified Cormack and Lehane grade and POGO score were recorded. Results: Intubation time was significantly lower in Glidescope group as compared to Fibreoptic group (67.79±20.79 vs 89.03±20.52) seconds respectively (P 0.0001), change of performer seen more with Fibreoptic group, (P 0.031). HR and MAP were significantly increased at5 and 10 minutes of post intubation in fibreoptic group as compared to glidescope group. Conclusion: Glidescope provides better hemodynamic stability with faster intubation and insignificantly higher first successful intubating attempt.