Purpose: To make a review by focusing upon various criterias and concepts of Gastro Retaintive Drug delivery System. Methods: This review is prepared by focusing on recent literatures on needs, advantages and disadvantages, factors affecting, suitable and unsuitable drugs, pharmacokinetic aspect, mechanism, approaches, list of polymers and other ingredients used, in vitro and in vivo evaluation, literature survey, marketed products, patented formulations, applications, limitations, and future aspect of Gastro Retaintive Drug Delivery system. Result: It is an Hydrodynamically Balanced System (H.B.S) or Low Density system (LDS) which improve the controlled delivery of drug that have an absorption window by continuously releasing the drug for prolonged period of time at desired rate before it reaches at absorption site and improve the bioavailability. Conclusion: The GRDDS can be considered as a Controlled Drug Delivery System (CDDS) in which ideal doses form attains the desired therapeutic concentration of drug in plasma and maintains constant frequency for entire duration of treatment.
Impact Factor
2022: 6.012
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