Context: HPV infection is a well recognized risk factor for cervical cancer and its precursors. HPV can be detected in pap smears well in advance of development of carcinoma and appropriate action can be taken. However, despite availability of various cervical cancer screening methods, as well as large burden of disease in India, routine screening is still not practised effectively.
Objective : This study was conducted to assess the burden of HPV infection, detected by pap smears and its association with cervical cancer and precursor lesions.
Material and methods: 200 pap smears from various age groups were randomly selected for cytological examination, and examined specifically for HPV induced changes, which was confirmed later by serological testing and the findings were correlated with the Bethseda category.
Results: Out of 200, 72 cases (36%) were HPV positive. Most of the carcinomas (87.5%), HSIL (88.9%) and LSIL (80%) were positive for HPV infection. 64.3% of ASC-US and 50% of ASC-H were also positive for HPV infection.
Conclusion : HPV infection of cervix is quite prevalent among females in India. Pap smear is good screening method to detect these cases, which may result in dysplasia and malignancy.
Impact Factor
2022: 6.012
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