The aim of our investigation was to formulate a liquid self microemulsifying drug delivery system (SMEDDS) of candesartan cilexetil that could help to improve its solubility, stability, and oral bioavailability. The SMEDDS was prepared by using mixture of drug, oil, surfactant and cosurfactant. The liquid formulation was evaluated for various tests like solubility, Drug-surfactant compatibility, particle size, zeta potential, in vitro dissolution, etc. The optimized formulation S1 showed drug release (99.91%), drug content (97.42%), droplet size (62 nm), Zeta potential (-24.2), PDI (0.228), viscosity (0. 8269 cP) etc. In vitro drug release of the S1 was highly significant 97.96% as compared with marketed preparation (M) 66.73%.
The present investigation shows that SMEDDS of Candesartan cilexetil can be formulated as a unit dosage form. The S1 can be further used for preparation of different solid dosage forms.
Impact Factor
2022: 6.012
This work is licensed under a