Formulation and evaluation of oral fast dissolving film

Background: To prepare and evaluate oral fast dissolving film.
Material and Methods: Oral fast dissolving films were prepared by solvent casting method.
Results: The maximum drug release was found to be 52.05 % in formulation F3. The tensile strength of the film as the concentration of plasticizer (Propylene Glycol and Glycerin) was increased, the tensile strength of formulation was found to be decreased. The decrease in tensile strength may be due to weakening of bond linkage between the polymer chains.
Conclusion: The formulation F3 containing HPMC as a film forming polymer and Propylene glycol as a plasticizer was selected as an optimized formulation because it gave higher plasticity, good in-vitro drug release and less tensile strength etc. Hence, finally it was concluded that the prepared film containing Clopidogrel is considered as a potentially useful dosage form used as antiplatelet agent.