The purpose of this study was to prepare tablet of Exenatide to deliver the drug to the colon in intact form which is used for the treatment of Type II diabetes. Type II diabetes is a chronic progressive disorder characterized by defective insulin secretion and increased insulin resistance. The drug Exenatide is very useful for the management of type II diabetes and also reduces the complications which are majorly observed in this disease i.e. conversion from Type II to Type I. As this drug is not as much stable in gastric pH because instead of absorption in blood it will get degraded in acidic environment so it is targeted to colon as colon shows best absorption for the macromolecular drugs.
In the present study, Exenatide tablet was formulated using approach of pH dependent drug delivery for targeting drug to the colon. The core tablets were prepared by using Protease inhibitor and Adsorption enhancer i.e. Na-EDTA and Chitosan which will get easily degraded by colonic enzymes. Tablet was compress coated by Eudragit S100 and Guar gum which will retard the drug release in upper GI Tract and in 6.8 pH it will give the drug release. The formulations of the batches were prepared.
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2022: 6.012
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