The objective of the study was to develop the oral dispersible tablets of various concentrations of polymers on in-vitro release rate from the prepared Atorvastatin calcium tablets. The effect of drug to polymer ratio on the in vitro drug release behavior was significant. Formulation F5 showed better in vitro drug release and this indicates the ideal drug, polymer and excipients combination formulations. In vitro dissolution results showed that maximum cumulative % drug release was more in formulation F5 when compared to formulation F1 to F9.Stability studies were conducted formulations F5 stored at 250C/60% RH and 400C/75% RH for 30 days. Various parameters like hardness, friability, drug content uniformity, in vitro disintegration, wetting time were analyzed at a time of interval of 10 days till a period of 30 days. Not much variation or change was observed in any parameters throughout the study period. Best –selected formulations F5 found to be stable. Hence it is concluded that The prepared tablets disintegrate in seconds without need of water and enhance the absorption, this leads to increased bioavailability of Atrovastatin calcium.
The results of stability study on Formulation F5 after a period of one month indicates that the formulation was stable. Based on result it is concluded that formulated oral dispersible tablet of atrovastatin may have wide acceptance as compared to conventional dosage form.
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