The aim of present research work is to develop an ideal floating drug delivery system using Atorvastatin calcium to increase the gastric residence time in stomach and also to assess the in-vitro quality control tests for prepared tablet formulation. Materials and Methods: In this study Atorvastatin calcium tablets were prepared using xanthan gum, PVPK30 and HPMCK4M as polymers, sodium bicarbonate as gas releasing agents, citric acid and tartaric acid as acidifying agents, talc and magnesium stearate as flow promoters and avicel pH 101 as a diluent. Direct compression method was used by using a rotary compression machine. Before compression, granular material was evaluated for precompression parameters such as angle of repose, bulk density, tapped density, carr’s index and hausner’s ratio. After punching, tablets were evaluated for weight variation, friability, hardness, drug content, floating lag time, buoyancy and cumulative percent drug release. The formulations were optimised for different concentrations of HPMCK4M and xanthan gum and their formulations. Optimized formulations were subjected to stability studies and characterization by FTIR. Results and Discussion: All prepared tablets showed good in-vitro buoyancy for >9 to>24hours. Optimized formulation showed cumulative percent drug release of 92.8±0.12%, buoyancy lag time 41±0.09sec and duration of buoyancy >24±0.3. Release kinetics of optimized formulation showed zero order with non-fickian diffusion. Conclusion: Out of all nine formulations, F6 has 80mg of xanthan gum was considered as best formulation based on buoyancy, swelling studies and drug release mechanism corresponds to zero order and non-fickian diffusion.
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2022: 6.012
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