Formulation and devlopment of oral controlled release tablet of sucralfate and metoprolol succinate as floating drug delivery system

The present research deals with formulation and development of 150 mg oral controlled release tablet (Bi-Layered Floating Tablet) containing 100 mg of Ulcer protective Sucralfate as immediate release layer and 50 mg of Antihypertensive Metoprolol Succinate as floating sustained release layer having tablet wt 500 mg. Drug - exipients compatibility study, preparation and evaluation of 10 formulation of Sucralfate and 10 formulations of Metoprolol succinate is done and best formulations are selected. Then Bi-Layered floating tablet is prepared and evaluated. By in vitro study it is found that In presence of maximum % of Sodium bicarbonate, Magnesium oxide, and Sodium CMC the Sucralfate layer (SF9) produce disintegration time 0.58 ± 0.075 minutes and drug content 99.23 %.in stomach medium and In presence of maximum % of Metoloze, Acrilic acid, and Aerosil the Metoprolol succinate layer (MSF10) produce FLT 12sec, TFT >24 hours.in upper intestinal phase. Then Bi Layered floating tablet (SFMS) is compressed having tablet weight 500 mg with formulations (SF9 + MSF10) . In vitro evaluation of SFMS produce DT 2.04± 0.157 min ,FLT 10sec,TFT >24hrs,and drug content 99.98% . So it is confirmed that the formulation (SF9 +MSF10 ) produce better Floating Drug Delivery system.