Evaluation of vitamin d and oxidative stress status in patients of type2diabetes

India faces concurrent epidemics of T2DM and hypovitaminosis D, across all age groups in urban as well as rural regions. Vitamin D played an important role in the metabolism of glucose. It directly stimulates insulin secretion from beta cells of the pancreas. Besides, increased oxidative stress and decreased antioxidant defence are established etiological factors of this multi-factorial disease. This study intended to estimate the total oxidative stress, total antioxidant defence and vitamin D3 levels in type 2 recently diagnosed diabetic patients. A comparative study was conducted in the Department of Medicine, GMC Jammu in collaboration with the department of Biochemistry, GMC Jammu, on 30 recently diagnosed type 2 diabetic patients and equal number of age and gender matched healthy controls. The mean level of vitamin D3 in patients was 49.26±16.48 ng/ml which was lower than the corresponding mean values in healthy controls, ie 74.95±8.81 ng/ml. This study has given significant higher values of TOS and significant lower values for TAD in subjects as compared to the controls. The fact that T2DM is associated with increased oxidative stress and decreased antioxidant defence, the low levels of circulating plasma vitamin D3 seems to be associated with type 2 diabetic patients.