Aim: The aim of this study was to evaluate hs-CRP level in type 2 diabetic mellitus (T2DM) subjects associated with dyslipidemia. Methodology: The cross-sectional study was conducted in Department of Biochemistry and Medicine, S.P. Medical College & Associated group of PBM Hospitals, Bikaner. The serum fasting plasma glucose (FPG) and lipid profile were estimated by a fully automated Beckman coulter analyzer and hs-CRP was estimated by an electro-chemiluminescence system. Results: The mean levels of FPG, lipid profile and hs-CRP were significantly higher in diabetic patients associated with dyslipidemia. It was found that there was a significant positive correlation (p < 0.05) of increased hs-CRP with a raised level of FPG & lipid parameters while HDL-C in cases. Conclusion: hs-CRP and lipid profile measurements for vascular risk assessment in the diabetic patients for preventing cardiovascular complications. Chronicinflammation may have a role in vascular toxicity resulting in endothelial damage in T2DM. The early stage of diagnosis of T2DMmay have a important role for preventing cardiovascular disease in these patients.