The aim of this study was to evaluate the physical, mechanical properties and formaldehyde emission of the plywood made by using UF /pMDI Hybrid resin. In order to improve the water resistance properties, urea-formaldehyde resin are commonly modified with melamine or phenol. In this study water resistance properties of urea formaldehyde resin was enhanced by using polymeric isocyanate (pMDI) having terminal isocyanate –CNO group appx. 12,5 % with urea –formaldehyde resin . 12mm plywood was manufactured by using uf/pmdi resin developed in the laboratory scale and was taken for its performance study in terms of physical and mechanical properties like water resistance, glue shear strength, MOR,MOE etc. and statistical analysis was performed in order to examine possible feasibility of the UF/pMDI resin for manufacture of boiling water resistance plywood. From the analyzing data results shows that incorporation of 10% of pMDI in UF/pMDI resin significantly increases the water resistance, glue shear strength, MOR, MOE value of the plywood and formaldehyde content of the plyboard reduced up to 30% as compared to control sample tested as per IS:13745. The results of this study demonstrate that the UF/PMDI hybrid resin can be an alternate resin for improving the water resistance properties of the plywood.