Evaluation of the efficacy and toxicity with the use of diazepam in combination with pentazocine and ketamine as iv sedatives

Aim: Evaluation of the efficacy and toxicity with the use of diazepam in combination with pentazocine and ketamine as IV sedatives in minor oral surgical procedures.
Material and Methods: Patients undergoing minor oral surgical procedure were divided into two groups. One group was administered IV Ketamine and another group was administered IV pentazocine, both in combination with diazepam.
Results: A significant increase in heart rate and systolic pressure was seen in both the groups. A significant difference was seen in the respiratory rate and O2 saturation in Group 2 patients. The time of recovery is more in Group 1 than in Group 2 patients.
Conclusion: The administration of Pentazocine significantly reduced the mean dose of Diazepam required to produce satisfactory sedation, thereby reducing some of its side effects.