An ethnobotanical survey was carried out among the Kani tribe residing in the foot hills of Southern Western Ghats of Tamilnadu, India. Poisonous bite is the most common among the tribal people due to lack of sanitation. Tribal communities still depend upon wild medicinal plants for meeting the primary healthcare needs. In the present study, a total of 48 medicinal taxa belonging to 43 genera and 28 families used for the treatment of poisonous bites by the kani tribe. These medicinal plants are used to treat different types of poisonous bites such as snake bite, scorpion bite, spider sting, honey bee sting, dog bite, leech bite.