Situs inversus is a rare congenital anomaly with transposition of viscera in which the internal organs are reversed, as if in a mirror image of their normal position.. Endoscopic retrograde cholangiopancreatography (ERCP) in patients with situs inversus because of mirror image location of Upper GI tract and biliary system. Many positions and approaches are described for performing ERCP. However, we have performed ERCP in in conventional position without much difficulty, and we report two cases of situs inversus totalis who underwent ERCP in standard prone position and this is the First case report in patient who underwent Gastrojejunostomy (GJ)