The non-surgical endodontic treatment approach for tooth with open apex is always a challenging one. To get a perfect seal of the apical region under a complete asepsis of the canals cant be done by single antibiotics. So come the combination of triple antibiotics (metronidazole, ciprofloxacin, and minocycline) effectively against aerobic and anaerobic bacteria. Mineral trioxide aggregate (MTA) has the advantage of achieving optimal seal of the canals. This case report shows the success of the endodontic treatment of open apex tooth using Triple antibiotic paste in combination with MTA as the apical plug following 2 years of follow up.