Endocrine glands are the ductless glands capable of synthesizing and releasing special chemical messengers called hormones. Endocrine system together with the nervous system acts as the body’s communication system and it is composed of various endocrine glands and cells. Apart from other systemic signs they also produce signs in the oral cavity. These oral changes can sometime lead to their diagnosis. Therefore, the general dental practitioner should be well versed with the oral manifestations of these endocrine dysfunctions. The current review summarizes the various diagnostic features of the such disorders.