In the recent years, scientific and technological advancements have been made in the research and development of novel drug delivery systems by overcoming physiological difficulty such as short gastric residence times and irregular gastric emptying times. Gastric emptying of dosage form is extremely variable process and ability to prolong and control the emptying time. Gastric transit time is valuable asset for dosage forms, which reside in the stomach for a long period of time than conventional dosage form. Many approaches at present uses the prolongation of the gastric residence times, including floating drug delivery systems, swelling and expanding systems, polymeric bio adhesive systems, modified shape systems, high density systems and other delayed gastric emptying devices. The drug from floating drug delivery systems can be absorbed in the upper parts of stomach, duodenum and jejunum. This is one of the best ideal approach for prolongation of gastric residence time of a drug for controlled and sustained release.
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2022: 6.012
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