Thirteen canines, naturally infested with sarcoptic, otodectic, or demodectic mange, of different breeds or mongrels, and of both sexes, were treated; a dermatological examination, analogous pruritus evaluation, and identification of lesions and the presence of ectoparasites were performed. The canines were treated with a sarolaner chewable tablet at a dose of 2 mg/kg (range 2–4 mg/kg).They were evaluated on days 14, 30, 44, and 60 post-treatment, and all patients showed significant improvement at the different evaluation days, showing no adverse effects.