In order to break the chain of blood borne disease transmission brought on by unsafe injection practices, which put patients and healthcare professionals at risk for infectious and non-infectious adverse events, it is crucial that nurses have solid information and employ competent practices. Patients, the public, and injection providers (healthcare professionals) all bear responsibility for dangerous injection practices. Due to, unsafe practices like recapping needles, handling used sharps (bending, breaking, or cutting hypodermic needles), passing sharps from one healthcare worker to another, and carelessly leaving sharps in unexpected places, injection providers are at risk of needle stick injuries. To avoid these incidences, the concerned study has been taken up to assess the effectiveness of Poster display on Safe Injection Practice regarding knowledge & skill among staff nurses, from January 2023 to June 2023 which depicts a significant increase in knowledge level of nurses ‘whose ‘t’ value is 15.147 at 0.05 level & on the other hand for determination of skill, ‘t’ test value is 31.53 at 0.05 level which shows a significant increase in skill level of nurses ‘on Safe Injection Practices.