Controlled land application of post biomethanated spent wash @ 75 000 L ha-1 as a liquid manure for pearl millet crop in Inceptisol was conducted to study effect on soil properties, nutrient uptake and on yield. The post bio-methanated spent wash a distillery effluent was neutral to slightly alkaline in reaction, contain high amounts of soluble salts , rich in plant nutrients and Low in BOD (6000 ppm) and COD (28,000 ppm).Land application recorded increased in bulk density, hydraulic conductivity and remarkable change in pH and EC of soil. The improvement in major nutrients, micronutrients and microbial population was noticed in soil after harvest of crop. Significantly increased in total uptake of N,P,K and yield over untreated plots.