The present study aims to study the protective effects of chestnut fruits (Castanea sativa,L.) such as rickets and osteoporosis in female rats. The present study carried out on thirty female albino rats (Sprague Dowely) weighing 150 ±5 g. The first group kept as negative control group which fed on standard diet only while the other five groups received injected with by methyl prednisolone acetate (0.2 mg/kg/b.wt./rats) injected subcutaneously to induce osteoporosis. One group served as positive control group while others groups treated with chestnut juice levels at 100, 200 and 300 ml/kg for six weeks. The results revealed that all of the curative groups showed significant increases in feed intake, body weight gain and femur bone/body weight, in addition to the emergence of a significant improvement in BMD, BMC, serum calcuim, ionized Ca, P serum estrogen, osteocalcin and alkaline phosphatase, reduced glutathione, catalase and hydrogen peroxide comparing to positive control group. Also nutritional values and lipid profile have been recorded. Our results demonstrate that chestnut juice have beneficial effects on osteoporosis risk factors that extend beyond the reduction of the symptoms of arthritis of the bones, called osteoarthritis.
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