An effect of the multiprobiotic “symbiter acidophilic” concentrated on the level of expression of mrna gene ptgs2 and tgfb1 in rats liver with monosodium glutamate-induced steatohepatosis

The studies were conducted on the experiment with 30 white male rats. Newborn infant rats were divided into 3 groups with 10 rats in each group. The first group performed as a control value. The second group rats in the early neonatal period were injected with monosodium glutamate (MSG) at a dose of 4 mg/g. These rats were accessed to have visceral adiposity and steatohepatosis. The third group rats (after neonatal injection of MSG) periodically were injected multiprobiotic “Symbiter acidophilic concentrated” (0,14 ml/kg orally) starting from the first month after the birth. In the rats liver of 4 month old we determined the level of expression of mRNA gene Ptgs2 and Tgfb1.
In comparison with animals of control group, in the rats liver after neonatal injection of MSG the level of expression of mRNA gene Ptgs2 which involved in the inflammatory conditions was increased in 8,2 times and the level of expression of mRNA gene Tgfb1 which involved in extension of fibrosis in the liver tissues was increased in 1,7 times. The rats with steatohepatosis (after neonatal injection of MSG) which were injected with “Symbiter acidophilic concentrated”, the levels of mRNA gene Ptgs2 and Tgfb1 expression returned to control values.