Effect of iv magnesium sulphate on intra-operative hemodynamics in patients undergoing total laparoscopic hysterectomy

Introduction: The field of laparoscopic surgery has evolved and grown tremendously with the aim of early recovery and reduced post-operative care and hospital stay Smooth conduction of these surgeries requires better hemodynamic control intraoperatively Serum magnesium suppresses vasopressin and catecholamine levels that increase during laparoscopy. It potentiates the action of non depolarizing muscle relaxants and decreases potassium release in response to succinylcholine. Hence, this study was conducted to assess the effect of IV Magnesium sulphate on intraoperative hemodynamics in patients undergoing total laparoscopic hysterectomy.
Material and Methods: This cross-sectional, observational study was conducted after obtaining the due permissions from the research advisory committee & Institutional Ethics Committee. A hundred female patients between 30 - 60 years of age & ASA I, ASA II with a BMI between 18.5 – 30.0 kg/m2 willing to undergo elective laparoscopic hysterectomy under general anesthesia. The study group M received IV Magnesium Sulphate in a dose of 30 mg/Kg in 100 ml normal saline15 minutes prior to induction. The placebo Group N received 100 ml Normal Saline 15 minutes prior to induction. The hemodynamic parameters viz Pulse rate (PR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) Mean Arterial Pressure (MAP) of both groups were recorded intraoperatively. The P Value < 0.05 was considered as level of significance.
Result: The difference between the Age and BMI of the two groups was found to be statistically non-significant (P>0.05). For the baseline, difference between the mean values of the two groups was found to be statistically non-significant (P 0.05) For all other time intervals, the difference between the mean values of the two groups was found to be statistically significant (P 0.05). The HR & MAP values of the Group M are significantly lower than that of the Group N at all time intervals
Conclusion: The hemodynamic response to laryngoscopy and carboperitoneum was blunted in the group receiving IV Magnesium as compared to the normal saline group.